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Genetic Screening of Cancer


The Cancer Genetics Screening provides information to individuals who may be at increased risk of cancer due to a personal history of cancer, family history of cancer or an underlying genetic condition. The goal of the screening is to let people aware of the cancer risk, cancer genetics, genetic testing, early detection, improved cancer management and possible risk reduction.

Scientists are trying to better understand which people are more likely to get certain types of cancer. They also study the things we do and the things around us to see if they cause cancer. This information helps doctors recommend genetic screening for cancer, which genetic screening tests should be used, and how often the tests should be done.

Researchers have identified 20 to 30 cancer-susceptibility genes that greatly increase a person's odds of getting some form of malignancy. For example, a gene has been identified on chromosome number 9 that may be linked to a common skin cancer called basal cell carcinoma. This gene labeled PTC or patched, may someday be important in screening for this type of cancer. Another gene, called HNPCC, is carried by one out of every 300 Americans and may greatly increase an individual's chance of getting colon cancer. And the doubly dangerous gene called BRCA-1 seems to give women an 85% chance of developing breast cancer, as well as a 50% chance of ovarian tumors.

People may consider the follwoing things both mother’s and father’s side of the family before taking the test:

If any of the relatives had cancer, including cancers of the breast, ovary, skin, prostate, thyroid, uterus (endometrium) or colon
If a relative developed cancer before the age of 50
If a family member had an unusual or rare type of cancer, such as male breast cancer
If a relative had more than one type of cancer, such as breast and ovarian cancer or cancer in both breasts
If he/she is concerned about their risk for developing cancer
if he/she wondered whether they should have genetic testing for cancer genes


List of Genetic Tests for Cancer

• BRCA 1 and BRCA 2 (common 3 founder mutations)

• BRCA 1 mutation (24 exons by sequencing)

• BRCA 1 deletion/duplication

• BRCA 2 mutation (27 exons by sequencing)

• BRCA 2 deletion/duplication

• BRCA 1 and BRCA 2 mutation (by sequencing)

• Breast Cancer Her 2 gene amplification- F.I.S.H

• MLH1 /MSH 2 deletion/duplication

• MLH1/MSH2 Micro satellite Instability (MSI)

• Bcr/Abl dual probe (CML)- F.I.S.H

• Small Cell Cancer of Lung- EGFR mutation- F.I.S.H

• Translocation 8/ 21 probe (Acute Myelogenous Leukemia)- F.I.S.H

• Translocation 8/ 14 (Burkitts Lymphoma, others)- F.I.S.H

• Melaris- Genetic Test for Hereditary Melanoma


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