P.O.Box 212671, Dubai, UAE.
Tel: +971 4 369 2061 Fax: +971 4 3683 762
Email: info@easternbiotech.com
Web:www.easternbiotech.com
Eastern Biotech & Life Sciences offers Foodprint
200+ test. The result is available within 3days time.
The Foodprint 200+ is a rapid reliable colorimetric microarray-based ELISA
test for the measurement of IgG antibodies for up to 221 foods that is
performed by whole blood, serum or plasma.
Up to 221 foods have been microarrayed onto each of 16 nitrocellulose
pads on a glass microscope slide. Non-specific binding sites are blocked
with blocking buffer prior to incubation with diluted patient whole blood,
serum or plasma. Anti-human IgG conjugated to horseradish peroxidase is
added to the pads, and this binds to food extract-bound antibodies in
the second incubation. The optical densities of the standards, positive
and negative controls and samples are measured using a high resolution
flat bed scanner with associated software. Optical density is directly
proportional to antibody activity in the sample.
Non-allergic food hypersensitivity is the medical name for food intolerance,
loosely referred to as food hypersensitivity. It is a delayed, negative
reaction to a food, beverage, food additive, or compound found in foods,
which involves symptoms in one or more body organs and systems, but is
not a true allergy. The precise distinction between food intolerance and
a food allergy is often missed. A true food allergy requires the presence
of IgE antibodies against the food. Food intolerance involves the immune
system, mediated by IgG antibodies.
Most of the Food Intolerance Tests that are available to detect the intolerance,
use ELISA test ( Immu Pro or York Test) to detect IgG antibody responses
against the foods. ALCAT test is performed using modified coulter counter,
which counts and sizes white blood cells before and after incubation with
specially prepared propietary gels that contains the different food items
to be tested. Food Print test utilizes state-of the-art Genarrayt(R) Microarray
technology to detect food specific IgG antibodies.Genarrayt(R) microarray
is produced by printing hundreds of protein spots onto a specially-prepared
glass slide each spot measureing only 130 μm across. The advantage of
FoodPrint over the other tests are as follows:
- Works with whole blood, plasma or serum
- 5 µL sample volume means less invasive sampling
- Highly miniatured- 1 slide instead of 80 µL plates
- 64 samples assayed in less than 2 hours so the turn around
time is only 3 days
- Flexible array design allowing for dietary variation
- High throughput multiplex assay for over 200 food antibodies
- Comparatively cheaper
Non-IgE-mediated food hypersensitivity (food intolerance) is more chronic, less acute, less obvious in its presentation, and often more difficult to diagnose than a food allergy. Symptoms of food intolerance vary greatly, and is often mistaken for the symptoms of a food allergy.
While true allergies are associated with fast-acting immunoglobulin IgE responses, it is difficult to determine the offending food causing a food intolerance because the response generally takes place over a prolonged period of time. Thus the causative agent and the response are separated in time, and may not be obviously related.
Food intolerance symptoms usually begin about half an hour after the food intake, but sometimes symptoms may be delayed up to 48 hours.
.
- On the skin, includes skin rashes, urticaria (hives), angioedema,
dermatitis, and eczema.
- Respiratory tract symptoms include nasal congestion, sinusitis,
pharyngeal irritations, asthma and an unproductive cough.
- GIT symptoms include mouth ulcers, abdominal cramp, nausea, gas, intermittent diarrhea, constipation, irritable bowel syndrome, and including anaphylaxis.
Food intolerance has also been found associated with; inflammatory bowel disease, eosinophilic esophagitis, functional dyspepsia, chronic hepatitis C infection, eczema. NSAID intolerance, respiratory complaints, including rhinitis and headache.
Foods are usually digested and disintigrated into their component parts e.g. amino acids, glycerides etc. These pass harmlessly through the gut into the bloodstream. However, sometimes small fragments of partially digested or undigested foods are able to pass through the gut wall into the bloodstream where they are recognized by the immune system as being ‘foreign’. The immune system then responds as if these food particles were a foreign body and makes antibodies (IgGs). In some patients, inflammation or irritation of the gut lining allows partially digested foods to leak into the bloodstream. This condition is called ‘leaky gut syndrome’ or ‘altered intestinal permeability’ and patients with this condition typically have high levels of antibodies to multiple foods.
IgG antibodies at high levels combine with the protein in the food to form an ‘antigen-antibody complex’. These complexes are usually eliminated by other cells in the immune system. However, if the immune system is overloaded, these molecules can become deposited in various body organs like brain, head, lung tissue, gastro-intestinal tract, skin and joints where they produce symptoms such as headaches, asthma, irritable bowel syndrome, eczema and rashes, and arthritis.
Diagnosis of food intolerance includes hydrogen breath testing for lactose intolerance, fructose malabsorption and professionally supervised elimination diets. The blood test called ELISA test is done to detect IgG mediated immune response to specific foods so that it helps to eliminate certain diets or poorly tolerated foods.
The antigen leukocyte cellular antibody test (ALCAT) has been commercially promoted as an alternative, but has not been reliable shown to be of clinical value.
ELISA is a standard diagnostic procedure used in medical set-up for many tests such as detection of viruses and detection of other antibodies.. The food ELISA test measures antibodies to foods. These antibodies are also known as food immunoglobulins or food IgGs.
Minor dietary changes can prevent severe reaction caused by certain food products, and for many this is adequate without the need of professional assistance. Persons unable to isolate foods and those more sensitive or with disabling symptoms should seek expert medical and dietitian help.
Depending upon the report, general practitioner will guide the person regarding further management. Food elimination tests can be carried on the patients to identify the problem food and chemicals.
Once all food chemical sensitivities are identified, it will help the dietitian to suggest an appropriate diet for the individual, for example: avoiding certain foods with those chemicals. A dietitian will ensure adequate nutrition is achieved with safe foods and supplements if needed.
Please contact us for further details at: 04 3692061 or email us: info@eastrenbiotech.com
The consultation may be conducted either through email, telephone call arranged by us or where possible, in person coordinated by our staff.
- Common abdominal pain may be due to a potentially treatable
newly recognized inflammatory reaction, 20. September 2007, www.news-medical.net/news
As many as one in four people in westernized countries experience pain or discomfort in their upper abdomen, and physicians have almost nothing to offer except anti-acid medicines, which usually don't work.
Now, in a small but novel study, researchers have found evidence that an abnormal amount of inflammatory cells populates the upper intestine of affected individuals, which suggests a fresh way of understanding the common complaint.
“Newly-designed, targeted anti-inflammatory medicine aimed at blocking the function of these cells might be very useful, if our results are validated,” says the study's lead researcher, Nicholas J. Talley, M.D., Chair of Internal Medicine at Mayo Clinic in Jacksonville.
“We are quite intrigued by what we have discovered, because it probably represents a new disease entity, one that might be capable of diagnosis and management,” Dr. Talley says.
The researchers found significantly more eosinophil cells in people with nonulcer dyspepsia, compared to the control group population, but these cells were found only in the duodenum, the place in the intestine where most chemical digestion takes place. Eosinophils are white blood cells, part of the immune system, which fight parasites.
The researchers cannot yet say whether duodenal esoinophilia is the cause of the pain or an effect of another factor causing the disorder, although Dr. Talley says “a casual link remains our hypothesis.
“The presence of these cells has been overlooked because no one has used rigorous quantification methods before, and because biopsy examinations of the duodenum are not routinely performed,” he says. “Now we have a new direction to go in.”
- Treatment for food intolerance, May24, 2004, www.medicalnewstoday
At the moment, there aren't any medicines that can cure food intolerance, so the only way to prevent a reaction is to avoid the particular food. Many children with food allergy grow out of it, but some people with allergies to peanuts, nuts from trees, fish and shellfish will have the condition for life.
It's important for anyone who thinks they might have a food intolerance, including a food allergy, to visit their GP, who can then refer them to a specialist, if appropriate, for a proper diagnosis. Once the diagnosis has been made, they should avoid the food that is known to trigger a reaction.
Epinephrine (adrenaline) is the recommended treatment for controlling a severe allergic reaction. It's available on prescription in special 'pens' (EpiPen or AnaPen), which can be used to inject the drug. If someone has a severe food allergy, he/she must always keep adrenaline with them so, if accidentally eat something they are allergic to, they can inject themselves before getting urgent medical help.
- CNS is one of the provider of CE marked tests for food intolerance,
www.camnutri.com
Cambridge Nutritional Sciences Ltd (CNS) is a subsidiary of Omega Diagnostics Group PLC, a provider of diagnostic products for use in hospitals, clinics and laboratories in over 100 countries.
CNS specialises in the field of immunodiagnostics and offers to both healthcare professionals and the general public a wide range of CE Marked tests for food intolerance and other conditions.
FoodPrint (R) is a highly sensitive and accurate laboratory service that detects the presence of of IgG food specific antibodies to a wide range of foods.
- Omega Diagnostics FY '09 Sales Buoyed by Array-Based Food
Testing Business, April 20, 2010, www.genomeweb.com
The British company expects to report "substantial growth" in its food intolerance testing line for full-year 2009, and sales of its microarray-based Genarrayt platform are expected to rise 44 percent to £1.04 million from £72,000 in 2008.
Contact Us
Eastern Biotech & Life Sciences FZ-LLCP.O.Box 212671, Dubai, UAE.
Tel: +971 4 369 2061 Fax: +971 4 3683 762
Email: info@easternbiotech.com
Web:www.easternbiotech.com